• It is known that the normal cells prefer to utilize glycolysis and further oxidative phosphorylation for cellular energy production.
• However, the “urgent” cells, e.g., inflmmatory cells, reprogram to shunt to lactate production from acetyl-CoA by down-regulation of Kreb cycle, and this phenonemon is calls “Warburg effect”.
• The Yonsei Food Immunology Lab pioneers the dietary rescue of cellular energy metabolism to Kreb cycle and further oxidative phosphorylation for phenotypical change of inflammatory cells to normal status.

Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis